Team 3 presentation, Session 4. Matriglycan function in the central nervous system and neuromuscular junction.
ALL students to read all papers in preparation for in class discussion

Team 3 papers to present:

Moore SA, Saito F, Chen JG, Michele DE, Henry MD, Messing A, Cohn RD, Ross-Barta SE, Westra S, Williamson RA, et al. Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature, 418:422-425.
DOI: 10.1038/nature00838
Campanelli, J.T., Roberds, S.L., Campbell, K.P. and Scheller, R.H. A Role for Dystrophin-Associated Glycoproteins and Utrophin in Agrin-Induced AChR Clustering. Cell 77:663-674, 1994.
DOI: 1016/0092-8674(94)90051-5
Grady, R., Zhou, H., Cunningham, J. M., Henry, M. D., Campbell, K. P., & Sanes, J. R. (2000). Maturation and Maintenance of the Neuromuscular Synapse. Neuron, 25(2), 279–293.
DOI: 1016/s0896-6273(00)80894-6

Background Reading

Longman C, Brockington M, Torelli S, Jimenez-Mallebrera C, Kennedy C, Khalil N, Feng L, Saran RK, Voit T, Merlini L, et al. Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Hum Mol Genet, 12:2853-2861.
DOI: 10.1093/hmg/ddg307
Saito F, Moore SA, Barresi R, Henry MD, Messing A, Ross-Barta SE, Cohn RD, Williamson RA, Sluka KA, Sherman DL, et al. Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron, 38:747-758.
DOI: 10.1016/s0896-6273(03)00301-5

Ohlendieck, K., Ervasti, J.M., Matsumura, K., Kahl, S.D., Leveille, C.J. and Campbell, K.P. Dystrophin-Related Protein is Localized to Neuromuscular Junctions of Adult Skeletal Muscle. Neuron 7:499-508, 1991.
DOI: 1016/0896-6273(91)90301-f
Satz JS, Barresi R, Durbeej M, Willer T, Turner A, Moore SA, Campbell KP. 2008. Brain and eye malformations resembling Walker-Warburg syndrome are recapitulated in mice by dystroglycan deletion in the epiblast. J Neurosci, 28:10567-10575.
DOI: 1523/JNEUROSCI.2457-08.2008